Vitamin A (as natural Beta Carotene; from Blakeslea trispora), Vitamin C (as natural L-ascorbate), Vitamin D3 (as Cholecalciferol; from wild harvested lichen), Vitamin E (from rice bran; containing α, β, δ, & φ Tocopherols), Thiamin (as Thiamine HCl), Riboflavin (from organic guava), Niacin (as Niacinamide), Pantothenic Acid (as D-Calcium Pantothenate), Iodine (from organic kelp), Zinc (as zinc amino acid chelate), Selenium (as selenium amino acid chelate), Copper (as copper amino acid chelate), Manganese (as citrate), Chromium (organically bound with GTF activity), L-Lysine HCL, Skin Cleanse & Detox Blend: L-proline, Organic Chlorella Algae (broken cell wall), Spirulina Algae Powder, Dandelion Leaf Extract (4:1), Beetroot Powder (root), Oregon Grape Powder (root; Mahonia aquifolium), Organic Apple Powder (fruit), Organic Elderberry Powder (fruit), Organic Blueberry Powder (fruit), Organic Milk Thistle Extract (whole plant); Vegan Omega-3 (providing EPA & DHA), Skin Probiotic Blend (2 Billion CFU***): L. rhamnosus GG, L. acidophilus, L. casei, L. plantarum, B. bifidum. Other Ingredients: Methylcellulose Capsule.

Take 2 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.

CAUTION: Do not exceed recommended dose. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Pregnant or nursing mothers and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Use only as directed. If gastrointestinal discomfort (including bloating, cramps, diarrhea, or other digestive upset) or other sensitivity is experienced stop taking the product immediately. If you are pregnant, nursing, or have a medical condition, please consult with your physician before use. If you have any questions about consuming this dietary supplement, consult with your healthcare provider before using. If you use prescription drugs or over-the-counter medications, are unaware of your current medical condition or have a pre-existing medical condition(s), consult with your health care professional before using. Discontinue use immediately if you experience any adverse symptoms or reactions while taking this product. Discontinue use 2 weeks prior to surgery. Do not use if your health status is unknown. Do not use if safety seal is damaged or missing. Keep out of reach of children and pets. This product is intended for healthy adults, and individuals 12 years of age or older. Individuals between the ages of 12 and 18 should take this product under the supervision of an adult. Store in a cool, dry place, away from heat moisture. Use this product as a food supplement only. Do not use for weight reduction.

Vitamins & Minerals

Mrinal Gupta, Vikram K. Mahajan, Karaninder S. Mehta, Pushpinder S. Chauhan, "Zinc Therapy in Dermatology: A Review", Dermatology Research and Practice, vol. 2014, Article ID 709152, 11 pages, 2014. DOI: 10.1155/2014/709152

Brandt, Staci. “The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systematic review of the literature.” Journal of drugs in dermatology : JDD vol. 12,5 (2013): 542-5. PMID: 23652948

Dreno, B et al. “Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate in the treatment of inflammatory acne vulgaris.” Dermatology (Basel, Switzerland) vol. 203,2 (2001): 135-40. DOI: 10.1159/000051728

Yee, Brittany E et al. “Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.” Dermatologic therapy, e14252. 29 Aug. 2020, DOI: 10.1111/dth.14252

Dhaliwal, Simran et al. “Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence.” American journal of clinical dermatology vol. 21,1 (2020): 21-39. DOI: 10.1007/s40257-019-00484-0

Ozuguz, Pinar et al. “Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris.” Cutaneous and ocular toxicology vol. 33,2 (2014): 99-102. DOI: 10.3109/15569527.2013.808656

Rostami Mogaddam, Majid et al. “Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris.” BioMed research international vol. 2014 (2014): 474108. DOI: 10.1155/2014/474108

Ikaraoha, C I et al. “The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population.” Biological trace element research vol. 176,2 (2017): 251-257. DOI: 10.1007/s12011-016-0839-4

Gupta, Mrinal et al. “Zinc therapy in dermatology: a review.” Dermatology research and practice vol. 2014 (2014): 709152. doi: 10.1155/2014/709152

Ogawa, Youichi et al. “Zinc and Skin Disorders.” Nutrients vol. 10,2 199. 11 Feb. 2018, doi: 10.3390/nu10020199

Keen, Mohammad Abid, and Iffat Hassan. “Vitamin E in dermatology.” Indian dermatology online journal vol. 7,4 (2016): 311-5. doi: 10.4103/2229-5178.185494

Nachbar, F, and H C Korting. “The role of vitamin E in normal and damaged skin.” Journal of molecular medicine (Berlin, Germany) vol. 73,1 (1995): 7-17. DOI: 10.1007/BF00203614

Schagen, Silke K et al. “Discovering the link between nutrition and skin aging.” Dermato-endocrinology vol. 4,3 (2012): 298-307. doi: 10.4161/derm.22876

Eberlein-König, B et al. “Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E).” Journal of the American Academy of Dermatology vol. 38,1 (1998): 45-8. DOI: 10.1016/s0190-9622(98)70537-7

Kafi, Reza et al. “Improvement of naturally aged skin with vitamin A (retinol).” Archives of dermatology vol. 143,5 (2007): 606-12. DOI: 10.1001/archderm.143.5.606

Zasada, Malwina, and Elżbieta Budzisz. “Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments.” Postepy dermatologii i alergologii vol. 36,4 (2019): 392-397. doi: 10.5114/ada.2019.87443

Mukherjee, Siddharth et al. “Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.” Clinical interventions in aging vol. 1,4 (2006): 327-48. PMCID: PMC2699641

Telang, Pumori Saokar. “Vitamin C in dermatology.” Indian dermatology online journal vol. 4,2 (2013): 143-6. doi: 10.4103/2229-5178.110593

Pullar, Juliet M et al. “The Roles of Vitamin C in Skin Health.” Nutrients vol. 9,8 866. 12 Aug. 2017, doi: 10.3390/nu9080866

Rattanawiwatpong, Pattarawan et al. “Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial.” Journal of cosmetic dermatology vol. 19,3 (2020): 671-676. doi: 10.1111/jocd.13305

Umar, Meenakshi et al. “Vitamin D and the Pathophysiology of Inflammatory Skin Diseases.” Skin pharmacology and physiology vol. 31,2 (2018): 74-86. DOI: 10.1159/000485132

Mostafa, Wedad Z, and Rehab A Hegazy. “Vitamin D and the skin: Focus on a complex relationship: A review.” Journal of advanced research vol. 6,6 (2015): 793-804. doi: 10.1016/j.jare.2014.01.011

Sadat-Ali, Mir et al. “Topical delivery of vitamin d3: a randomized controlled pilot study.” International journal of biomedical science : IJBS vol. 10,1 (2014): 21-4. PMCID: PMC3976443

Weber, Günther et al. “Vitamin D induces the antimicrobial protein hCAP18 in human skin.” The Journal of investigative dermatology vol. 124,5 (2005): 1080-2. DOI: 10.1111/j.0022-202X.2005.23687.x

Bikle, Daniel D. “Vitamin D and the skin.” Journal of bone and mineral metabolism vol. 28,2 (2010): 117-30. DOI: 10.1007/s00774-009-0153-8

Bikle, Daniel D. “Vitamin D metabolism and function in the skin.” Molecular and cellular endocrinology vol. 347,1-2 (2011): 80-9. DOI: 10.1016/j.mce.2011.05.017

MacLaughlin, J, and M F Holick. “Aging decreases the capacity of human skin to produce vitamin D3.” The Journal of clinical investigation vol. 76,4 (1985): 1536-8. DOI: 10.1172/JCI112134

Holick, M F et al. “Photosynthesis of previtamin D3 in human skin and the physiologic consequences.” Science (New York, N.Y.) vol. 210,4466 (1980): 203-5. DOI: 10.1126/science.6251551

L-Lysine HCL & Vegan Omega-3            

Baldwin, Hilary, and Jerry Tan. “Effects of Diet on Acne and Its Response to Treatment.” American journal of clinical dermatology, 10.1007/s40257-020-00542-y. 3 Aug. 2020. DOI: 10.1007/s40257-020-00542-y

Kiefer, David, and Traci Pantuso. “Omega-3 fatty acids: An update emphasizing clinical use.” Agro food industry hi-tech vol. 23,4 (2012): 10-13. PMID: 24436723

Huang, Tse-Hung et al. “Cosmetic and Therapeutic Applications of Fish Oil's Fatty Acids on the Skin.” Marine drugs vol. 16,8 256. 30 Jul. 2018. doi: 10.3390/md16080256

Pilkington, Suzanne M et al. “Omega-3 polyunsaturated fatty acids: photoprotective macronutrients.” Experimental dermatology vol. 20,7 (2011): 537-43. DOI: 10.1111/j.1600-0625.2011.01294.x

Tanghetti, Emil A. “The role of inflammation in the pathology of acne.” The Journal of clinical and aesthetic dermatology vol. 6,9 (2013): 27-35. PMID: 24062871

Rubin, Mark G et al. “Acne vulgaris, mental health and omega-3 fatty acids: a report of cases.” Lipids in health and disease vol. 7 36. 13 Oct. 2008. doi: 10.1186/1476-511X-7-36

Khayef, Golandam et al. “Effects of fish oil supplementation on inflammatory acne.” Lipids in health and disease vol. 11 165. 3 Dec. 2012. doi: 10.1186/1476-511X-11-165

Jung, Jae Yoon et al. “Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial.” Acta dermato-venereologica vol. 94,5 (2014): 521-5. DOI: 10.2340/00015555-1802

Neukam, K et al. “Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition.” Skin pharmacology and physiology vol. 24,2 (2011): 67-74. DOI: 10.1159/000321442

Yamauchi, Mitsuo, and Marnisa Sricholpech. “Lysine post-translational modifications of collagen.” Essays in biochemistry vol. 52 (2012): 113-33. doi: 10.1042/bse0520113

Singh, Meenu & Rao, Dowlathabad & Pande, Shivansh & Battu, Sowjanya & Rajeswar Dutt, Kunduri & Ramesh, Mantri. (2011). Medicinal Uses of L-Lysine: Past and Future. International Journal of Research in Pharmaceutical Sciences. 2.

Niacin &Thiamin

Walocko, Frances M et al. “The role of nicotinamide in acne treatment.” Dermatologic therapy vol. 30,5 (2017): 10.1111/dth.12481. DOI: 10.1111/dth.12481

Levin, Jacquelyn, and Saira B Momin. “How much do we really know about our favorite cosmeceutical ingredients?.” The Journal of clinical and aesthetic dermatology vol. 3,2 (2010): 22-41. PMID: 20725560

Bissett, Donald L et al. “Niacinamide: A B vitamin that improves aging facial skin appearance.” Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] vol. 31,7 Pt 2 (2005): 860-5; discussion 865. DOI: 10.1111/j.1524-4725.2005.31732

Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.

Park, Sang Min et al. “Niacin intake and risk of skin cancer in US women and men.” International journal of cancer vol. 140,9 (2017): 2023-2031. doi: 10.1002/ijc.30630

Alvarez, O M, and R L Gilbreath. “Thiamine influence on collagen during the granulation of skin wounds.” The Journal of surgical research vol. 32,1 (1982): 24-31. DOI: 10.1016/0022-4804(82)90180-9

Probiotic Blend

Kober, Mary-Margaret, and Whitney P Bowe. “The effect of probiotics on immune regulation, acne, and photoaging.” International journal of women's dermatology vol. 1,2 85-89. 6 Apr. 2015, doi: 10.1016/j.ijwd.2015.02.001

Lee, Young Bok et al. “Potential Role of the Microbiome in Acne: A Comprehensive Review.” Journal of clinical medicine vol. 8,7 987. 7 Jul. 2019. doi: 10.3390/jcm8070987

Dolan, Keren E et al. “Probiotics and Disease: A Comprehensive Summary-Part 6, Skin Health.” Integrative medicine (Encinitas, Calif.) vol. 16,4 (2017): 32-41. PMID: 30881255

Skin Herbals

Vostálová, Jitka et al. “Skin Protective Activity of Silymarin and its Flavonolignans.” Molecules (Basel, Switzerland) vol. 24,6 1022. 14 Mar. 2019. doi: 10.3390/molecules24061022

Hung, Chi-feng et al. “Topical delivery of silymarin constituents via the skin route.” Acta pharmacologica Sinica vol. 31,1 (2010): 118-26. doi: 10.1038/aps.2009.186

Dhanalakshmi, Sivanandhan et al. “Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.” Carcinogenesis vol. 25,8 (2004): 1459-65. DOI: 10.1093/carcin/bgh152

Gunes, Seda et al. “In vitro evaluation of Spirulina platensis extract incorporated skin cream with its wound healing and antioxidant activities.” Pharmaceutical biology vol. 55,1 (2017): 1824-1832. doi:10.1080/13880209.2017.1331249

Yang, Yafan, and Shuangshuang Li. “Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence.” Oxidative medicine and cellular longevity vol. 2015 (2015): 619560. doi: 10.1155/2015/619560

OyetakinWhite, Patricia et al. “Protective mechanisms of green tea polyphenols in skin.” Oxidative medicine and cellular longevity vol. 2012 (2012): 560682. doi: 10.1155/2012/560682

Katiyar, S K et al. “Green tea and skin.” Archives of dermatology vol. 136,8 (2000): 989-94. DOI: 10.1001/archderm.136.8.989

Clifford, Tom et al. “The potential benefits of red beetroot supplementation in health and disease.” Nutrients vol. 7,4 2801-22. 14 Apr. 2015. doi: 10.3390/nu7042801

Albaugh, Vance L et al. “Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing.” The Journal of nutrition vol. 147,11 (2017): 2011-2017. doi: 10.3945/jn.117.256404

Beitner, H. “Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin.” The British journal of dermatology vol. 149,4 (2003): 841-9. DOI: 10.1046/j.1365-2133.2003.05597.x

Oregon Health & Science University. "Pepper Compound Could Aid Millions With Vitiligo." ScienceDaily. ScienceDaily, 15 April 2008