Organic Full Spectrum Turmeric Blend: Fermented Turmeric (Rhizome)†, Turmeric Extract (Rhizome; Std. to 95% Curcuminoids)†, Fermented Turmeric Extract (Rhizome)†, Tumeric (Rhizome)†, Turmeric CO2 Extract (Rhizome)†, Organic Fermented Botanical Blend: Fermented Black Pepper Fruit Powder†, Fermented Ginger Root†, Fermented Long Pepper Fruit†, Sprouted Fermented Cumin Seed†, Fermented Black Pepper Fruit Oil†, Fermented Ginger Root CO2 Extract†, Stephania Root Extract (Stephania tetrandra)†, Indian Frankincense (Bark; Boswellia serrata)†, Ashwagandha Extract (Root & Leaf)†, Organic Fermented Bitter Botanical Blend: Fermented Milk Thistle Seed†, Fermented Dandelion Leaf†, Fermented Peppermint Leaf†, Fermented Peppermint Leaf Oil†, Fermented Reishi Mushroom (Fruiting Bodies)†, Fermented Apple Cider Vinegar†. Other Ingredients: Methylcellulose Capsule, Sunflower Lecithin, Phosphatidylcholine.

†Organic Ingredient.

Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.

CAUTION: Do not exceed recommended dose. It's important to know that one can't lose weight by use of the product alone, or without following a calorie controlled diet and exercise program. Weight loss results might not be effective for everyone and results might not be permanent. Pregnant, nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Keep out of reach of children and pets. Do not use if safety seal is damaged or missing. Store in a cool dry place. Use this product as a food supplement only. Do not use for weight reduction.

Turmeric

Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods. 2017;6(10):92. Published 2017 Oct 22. doi.org/10.3390/foods6100092.

Langhans, Sigrid. (2011). Therapeutic potential of curcumin in gastrointestinal diseases. World journal of gastrointestinal pathophysiology. 2. 1-14. DOI: 10.4291/wjgp.v2.i1.1

Adrian L Lopresti, The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?, Advances in Nutrition, Volume 9, Issue 1, January 2018, Pages 41–50, https://doi.org/10.1093/advances/nmx011

Chainani-Wu N. (2003). Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). Journal of alternative and complementary medicine (New York, N.Y.), 9(1), 161–168. DOI: 10.1089/107555303321223035

Zdrojewicz, Z., Szyca, M., Popowicz, E., Michalik, T., & Śmieszniak, B. (2017). Kurkuma – nie tylko przyprawa [Turmeric - not only spice]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 42(252), 227–230. PMID: 28662006

Gupta, S. C., Sung, B., Kim, J. H., Prasad, S., Li, S., & Aggarwal, B. B. (2013). Multitargeting by turmeric, the golden spice: From kitchen to clinic. Molecular nutrition & food research, 57(9), 1510–1528. DOI: 10.1002/mnfr.201100741

Curcumin

Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007). Bioavailability of curcumin: problems and promises. Molecular pharmaceutics, 4(6), 807–818. DOI: 10.1021/mp700113r

Aggarwal, B. B., Yuan, W., Li, S., & Gupta, S. C. (2013). Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Molecular nutrition & food research, 57(9), 1529–1542. DOI: 10.1002/mnfr.201200838

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195‐218. doi: 10.1208/s12248-012-9432-8

Gupta, S. C., Kismali, G., & Aggarwal, B. B. (2013). Curcumin, a component of turmeric: from farm to pharmacy. BioFactors (Oxford, England), 39(1), 2–13. DOI: 10.1002/biof.1079

Jurenka J. S. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative medicine review : a journal of clinical therapeutic, 14(2), 141–153. PMID: 19594223

Goel, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2008). Curcumin as "Curecumin": from kitchen to clinic. Biochemical pharmacology, 75(4), 787–809. DOI: 10.1016/j.bcp.2007.08.016

Ginger

Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J Prev Med. 2013;4(Suppl 1):S36–S42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665023/

Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Mir Taheri M. The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients. Iran J Pharm Res. 2015;14(1):131–140.

Hwang YH, Kim T, Kim R, Ha H. The Natural Product 6-Gingerol Inhibits Inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E₂ Levels. Int J Mol Sci. 2018;19(7):2068. Published 2018 Jul 16. doi: 10.3390/ijms19072068

Mao QQ, Xu XY, Cao SY, et al. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods. 2019;8(6):185. Published 2019 May 30. doi: 10.3390/foods8060185

Grzanna, R., Lindmark, L., & Frondoza, C. G. (2005). Ginger--an herbal medicinal product with broad anti-inflammatory actions. Journal of medicinal food, 8(2), 125–132. DOI: 10.1089/jmf.2005.8.125

Mao, Q. Q., Xu, X. Y., Cao, S. Y., Gan, R. Y., Corke, H., Beta, T., & Li, H. B. (2019). Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods (Basel, Switzerland), 8(6), 185. DOI: 10.3390/foods8060185

Bordia, A., Verma, S. K., & Srivastava, K. C. (1997). Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins, leukotrienes, and essential fatty acids, 56(5), 379–384. DOI: 10.1016/s0952-3278(97)90587-1

Ashwagandha

Sikandan, A., Shinomiya, T., & Nagahara, Y. (2018). Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines. International journal of molecular medicine, 42(1), 425–434. DOI: 10.3892/ijmm.2018.3608

Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43. Published 2015 Nov 25. doi: 10.1186/s12970-015-0104-9

Ziegenfuss, T. N., Kedia, A. W., Sandrock, J. E., Raub, B. J., Kerksick, C. M., & Lopez, H. L. (2018). Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial. Nutrients, 10(11), 1807. DOI: 10.3390/nu10111807

Kumar, G., Srivastava, A., Sharma, S. K., Rao, T. D., & Gupta, Y. K. (2015). Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study. The Indian journal of medical research, 141(1), 100–106. DOI: 10.4103/0971-5916.154510

Black pepper

Mair, Christina & Liu, Rongxia & Atanasov, Atanas & Schmidtke, Michaela & Dirsch, VM & Rollinger, Judith. (2016). Antiviral and anti-proliferative in vitro activities of piperamides from black pepper. Planta Medica. 81. S1-S381. DOI: 10.1055/s-0036-1596830

Butt, M. S., Pasha, I., Sultan, M. T., Randhawa, M. A., Saeed, F., & Ahmed, W. (2013). Black pepper and health claims: a comprehensive treatise. Critical reviews in food science and nutrition, 53(9), 875–886. DOI: 10.1080/10408398.2011.571799

Meghwal, M., & Goswami, T. K. (2013). Piper nigrum and piperine: an update. Phytotherapy research : PTR, 27(8), 1121–1130. DOI: 10.1002/ptr.4972

Srinivasan K. (2007). Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Critical reviews in food science and nutrition, 47(8), 735–748. DOI: 10.1080/10408390601062054

Tiwari, Anshuly & Mahadik, Kakasaheb & Gabhe, Satish. (2020). PIPERINE: A COMPREHENSIVE REVIEW OF METHODS OF ISOLATION, PURIFICATION AND BIOLOGICAL PROPERTIES. Medicine in Drug Discovery. 100027. DOI: 10.1016/j.medidd.2020.100027

Gülçin I. (2005). The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds. International journal of food sciences and nutrition, 56(7), 491–499. DOI: 10.1080/09637480500450248

Additional

Kotha RR, Luthria DL. Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects. Molecules. 2019 Aug 13;24(16):2930.

 Curcuminoids, a key class of active componds in turmeric are poorly soluble in water.  Studies in which turmeric/curcumin extracts are delivered in liposomal/lipid containing matrices demonstrate improved absorption of curcuminoids. See Page 6 Section 2.3, Section 3.0 and Table 1.

Turmeric provides antioxidant support

Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895.

See page 2891 Anti-inflammatory and Anti-oxidant Activity. Turmeric and its curcuminoid constituents are known to have antioxidant activity in vivo.