Vitamin A (as Beta Carotene [with Full- 1,585 mcg Spectrum Carotenoids]) Vitamin C (As L-Ascorbate & Acerola Cherry), Vitamin D3 (from Wild-Harvested Lichen), Vitamin E (as D-alpha Tocopherols; Tocotrienol & Tocopherol Complex), Niacin (as Natural Niacinamide), Vitamin B6 (as Pyridoxal-5-Phosphate), Folate (as L-5-Methyltetrahydrofolate), Vitamin B12 (as Methylcobalamin), Biotin, Pantothenic Acid (as Calcium Pantothenate), Iodine (from Kelp), Zinc (as Amino Acid Chelate), Selenium (L-Selenomethionine); Ultimate Hair Health Complex: Wild Caught Non-GMO Hydrolyzed Marine Collagen Peptides Types l & III, Organic Ashwagandha Extract (Root & Leaf), Organic Amla Berry Extract (Phyllanthus emblica), Horsetail Extract (Whole Plant; Equisetum ravens), Bio-Fermented Organic Turmeric Curcumin (Rhizome), Saw Palmetto CO2 Extract (Fruit), Organic Himalayan Shilajit Extract; Growth, Shine & Anti Gray Complex: L-Lysine, L-Arginine HCL, L-Gisteine HCL, L-Proline, L-Methionine, Catalase, Fo-Ti Root Powder, Resveratrol Extract 50% (Polygonum cuspidatum; Root), Tremella fuciformis (Silver Ear Mushroom; Sporocarp), Hyaluronic Acid; Hair Health Probiotic Blend 20B CFU***: L. helveticus, L. reuten, L. acidophilus, L. plantarum, B. lactis, L. rhamnosus, B. subtilis; Digestive Enzyme Hair Health Blend: Bromelain, Fungal Protease, Neutral Protease, Acid Stable Protease, Serratiopeptidase, Keratin, Omega-3 (with Plant-Based EPA & DHA from Algae), Silica (from Organic Bamboo), BioPerine® (Black Pepper Extract; Piper nigrum; Fruit), Inositol. Other Ingredients: Methylcellulose Capsule, Choline Bitartrate.

***At time of manufacture.

Adults take 4 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.

CAUTION: Do not exceed recommended dose. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Pregnant or nursing mothers and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Use only as directed. Some people might experience slight intolerance to marine or bovine product. If gastrointestinal discomfort (including bloating, cramps, diarrhea, or other digestive upset) or other sensitivity is experienced stop taking the product immediately. Some people are allergic to bovine (beef) or fish. If you are pregnant, nursing, or have a medical condition, please consult with your physician before use. If you have any questions about consuming this dietary supplement, consult with your health care professional before using. If you use prescription drugs or over-the-counter medications, are unaware of your current medical condition or have a pre-existing medical condition(s), consult with your health care professional before using. Discontinue use immediately if you experience any adverse symptoms or reactions while taking this product. Discontinue use 2 weeks prior to surgery. Do not use if your health status is unknown. Do not use if safety seal is damaged or missing. Keep out of reach of children and pets. Store in a cool, dry place, away from heat moisture. Biotin can be received in adequate or extra amounts from food and regular diet only. Use this product as a food supplement only. Do not use for weight reduction.

Essential nutrients to support healthy hair growth

Vitamin A and Carotenoids.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

VanBuren CA, Everts HB. Vitamin A in Skin and Hair: An Update. Nutrients. 2022 Jul 19;14(14):2952. doi: 10.3390/nu14142952. PMID: 35889909; PMCID: PMC9324272.

Vitamin C. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Vitamin D.  Health Professional Fact Sheet. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/

Vitamin E.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/

Niacin.  Health Professional Fact Sheet.  NIH.  https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/

Vitamin B6. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/

Folate.  Health Professional Fact Sheet.  NIH. https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/

Vitamin B12.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

Biotin.  Health Professional Fact Sheet.  NIH. https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/

Pantothenic Acid.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/

Choline.  Health Professional Fact Sheet.  NIH. https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/

Iodine.  Health Professional Fact Sheet. NIH.  https://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/

Zinc.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

Selenium. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/

Silicon.  Institute of Medicine. 2001. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: The National Academies Press. https://doi.org/10.17226/10026. [Note that silicon/silica is considered essential, however, no DV has been set for this nutrient.]

Vitamins C, E and Selenium for antioxidant support / to protect against free radical damage

Vitamin C. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Vitamin E.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/

Selenium. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/

Vitamin A, an essential vitamin that supports the formation of keratin, the key structural protein in hair

Vitamin A and Carotenoids.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

Vitamin A is involved in the expression of genes that regulate the production of keratin, a key structural protein found in hair and skin. 

Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. Available from doi: 10.17226/10026. See Background Section.

Vitamin B6, Folate, Biotin, Zinc and Selenium to support protein and amino acid metabolism

Biotin.  Health Professional Fact Sheet.  NIH. https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/

Folate.  Health Professional Fact Sheet.  NIH. https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/

Zinc.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

Vitamin B6. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/

Selenium. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/

Biotin

Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34. PMID: 23198010

Janos Zempleni, Yousef I Hassan & Subhashinee SK Wijeratne (2008) Biotin and biotinidase deficiency, Expert Review of Endocrinology & Metabolism, 3:6, 715-724, DOI: 10.1586/17446651.3.6.715

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981

S. Daniells and G. Hardy, “Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame?” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 13, no. 6, pp. 690–697, November 2010. doi: 10.1097/MCO.0b013e32833ece02

Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715

2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715

Sparavigna A, Tenconi B, La Penna L. Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial. Clin Cosmet Investig Dermatol. 2019;12:355‐362. Published 2019 May 13. doi: 10.2147/CCID.S187305

Lipner, S. R., & Scher, R. K. (2018). Biotin for the treatment of nail disease: what is the evidence?. The Journal of dermatological treatment, 29(4), 411–414. DOI: 10.1080/09546634.2017.1395799

Victor E. Colombo, Françoise Gerber, Max Bronhofer, George L. Floersheim. Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy. Colombo, Victor E. et al. Journal of the American Academy of Dermatology, Volume 23, Issue 6, 1127 – 1132. DOI: https://doi.org/10.1016/0190-9622(90)70345-I

Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi: 10.4103/0974-7753.188040

Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 41–48. PMID: 2648686

Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303–305. PMID: 8477615

Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782–787. PMID: 17763607

Keratin

Gavazzoni Dias MF. Hair cosmetics: an overview. Int J Trichology. 2015;7(1):2‐15. doi: 10.4103/0974-7753.153450

Bragulla HH, Homberger DG. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat. 2009;214(4):516‐559. doi: 10.1111/j.1469-7580.2009.01066.x

Basit A, Asghar F, Sadaf S, Akhtar MW. Health improvement of human hair and their reshaping using recombinant keratin K31. Biotechnol Rep (Amst). 2018;20:e00288. Published 2018 Oct 24. doi: 10.1016/j.btre.2018.e00288

Villa, A.L.V., Aragão, M.R.S., dos Santos, E.P. et al. Feather keratin hydrolysates obtained from microbial keratinases: effect on hair fiber. BMC Biotechnol 13, 15 (2013). DOI: 10.1186/1472-6750-13-15

Narda, Mridvika & Aladren, Sonia & Cestone, Enza & Nobile, Vincenzo. (2017). Efficacy and Safety of a Food Supplement Containing L-cystine, Serenoa repens Extract and Biotin for Hair Loss in Healthy Males and Females. A Prospective, Randomized, Double-blinded, Controlled Clinical Trial. Journal of Cosmetology & Trichology. DOI: 10.4172/2471-9323.1000127

Sando, L., Kim, M., Colgrave, M.L., Ramshaw, J.A.M., Werkmeister, J.A. and Elvin, C.M. (2010), Photochemical crosslinking of soluble wool keratins produces a mechanically stable biomaterial that supports cell adhesion and proliferation. J. Biomed. Mater. Res., 95A: 901-911. doi:10.1002/jbm.a.32913

Hydrolyzed Collagen

Wang, Bin & Yang, Wen & Mckittrick, Joanna. (2015). Keratin: Structure, Mechanical Properties, Occurrence in Biological Organisms, and Efforts at Bioinspiration. Progress in Materials Science. 76. DOI: 10.1016/j.pmatsci.2015.06.001

Yang FC, Zhang Y, Rheinstädter MC. The structure of people's hair. PeerJ. 2014;2:e619. Published 2014 Oct 14. doi: 10.7717/peerj.619

Krane, S.M. The importance of proline residues in the structure, stability and susceptibility to proteolytic degradation of collagens. Amino Acids 35, 703 (2008). DOI: 10.1007/s00726-008-0073-2

Shoulders MD, Raines RT. Collagen structure and stability. Annu Rev Biochem. 2009;78:929‐958. doi: 10.1146/annurev.biochem.77.032207.120833

Karna, E., Szoka, L., Huynh, T.Y.L. et al. Proline-dependent regulation of collagen metabolism. Cell. Mol. Life Sci. (2019). DOI: 10.1007/s00018-019-03363-3

Lodish H et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000. Section 22.3, Collagen: The Fibrous Proteins of the Matrix. https://www.ncbi.nlm.nih.gov/books/NBK21582/

Strnad P, Usachov V, Debes C, Gräter F, Parry DA, Omary MB. Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins. J Cell Sci. 2011;124(Pt 24):4221‐4232. doi: 10.1242/jcs.089516

Schor R, Krimm S. Studies on the Structure of Feather Keratin: II. A beta-Helix Model for the Structure of Feather Keratin. Biophys J. 1961 Jul;1(6):489-515. DOI: 10.1016/s0006-3495(61)86904-x

Multivitamins

Goluch-Koniuszy Z. Nutrition of women with hair loss problem during the period of menopause. Menopause Review/Przegląd Menopauzalny. 2016;15(1):56-61. DOI: 10.5114/pm.2016.58776

Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther (Heidelb). 2019;9(1):51‐70. doi: 10.1007/s13555-018-0278-6

Rajput, Rajendrasingh. (2018). A Scientific Hypothesis on the Role of Nutritional Supplements for Effective Management of Hair Loss and Promoting Hair Regrowth. Journal of Nutritional Health & Food Science. 6. 1-11. DOI: 10.15226/jnhfs.2018.001132.

Hyaluronic Acid

Park KJ, Lee SY, Kim HS, Yamazaki M, Chiba K, Ha HC. The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells. Mycobiology. 2007;35(1):11‐15. doi: 10.4489/MYCO.2007.35.1.011

Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91. Published 2018 Sep 9. doi: 10.3390/biomedicines6030091

Neste, Dominique & Tobin, Desmond. (2004). Hair cycle and hair pigmentation: Dynamic interactions and changes associated with aging. Micron (Oxford, England : 1993). 35. 193-200. DOI: 10.1016/j.micron.2003.11.006

Shi Y, Luo LF, Liu XM, Zhou Q, Xu SZ, Lei TC. Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors. PLoS One. 2014;9(4):e93589. Published 2014 Apr 2. doi: 10.1371/journal.pone.0093589

Kumar AB, Shamim H, Nagaraju U. Premature Graying of Hair: Review with Updates. Int J Trichology. 2018;10(5):198‐203. doi: 10.4103/ijt.ijt_47_18

Ruan, Yang & Li, Hong & Pu, Lianmei & Shen, Tao & Jin, Zening. (2018). Tremella fuciformis Polysaccharides Attenuate Oxidative Stress and Inflammation in Macrophages through miR-155. Analytical Cellular Pathology. 2018. DOI: 10.1155/2018/5762371

Daulatabad D, Singal A, Grover C, Chhillar N. Prospective Analytical Controlled Study Evaluating Serum Biotin, Vitamin B₁₂, and Folic Acid in Patients with Premature Canities. Int J Trichology. 2017;9(1):19‐24. doi: 10.4103/ijt.ijt_79_16

Bhat RM, Sharma R, Pinto AC, Dandekeri S, Martis J. Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children. Int J Trichology. doi: 10.4103/0974-7753.114706

Chakrabarty S, Krishnappa PG, Gowda DG, Hiremath J. Factors Associated with Premature Hair Graying in a Young Indian Population. Int J Trichology. 2016;8(1):11‐14. doi: 10.4103/0974-7753.179384

Chakrabarty S, Krishnappa PG, Gowda DG, Hiremath J. Factors Associated with Premature Hair Graying in a Young Indian Population. Int J Trichology. 2016;8(1):11‐14. doi:10.4103/0974-7753.179384

Daulatabad D, Singal A, Grover C, Chhillar N. Prospective Analytical Controlled Study Evaluating Serum Biotin, Vitamin B₁₂, and Folic Acid in Patients with Premature Canities. Int J Trichology. 2017;9(1):19‐24. doi: 10.4103/ijt.ijt_79_16