Medicinal Ingredients (per capsule): Cordyceps militaris (Stroma) 50 mg, Ganoderma lucidum, Reishi (Fruiting body) 50 mg, Hericium erinaceus, Lion’s Mane (Fruiting body) 50 mg, Magnolia officinalis, Magnolia Bark (Stem bark) 3.7 mg, Ophiocordyceps sinensis, Cordyceps (Stroma) 50 mg, Rhodiola rosea, Rhodiola (Rhodiola rosea - root) 50 mg, Vaccinium corymbosum, Blueberry (Edible fruit part) 50 mg, Withania somnifera, Ashwagandha (Root) 125mg, gamma-Aminobutyric acid, GABA (4-Aminobutanoic acid (Synthetic)) 150 mg. Non-Medicinal Ingredients: Methylcellulose Capsule.

Adults avoid taking before bedtime. Take with food/meal to avoid digestive upset. Take 2 capsules each day. Take at least one hour prior to taking medication or natural health products.

CAUTION: Consult a health care practitioner/health care provider/health care professional/doctor/ physician if symptoms persist or worsen. Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you have high blood pressure. Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you have liver disease, kidney disease and/or a seizure disorder. Do not use if you have gastrointestinal irritation. Stop use and consult a health care practitioner/health care provider/health care professional/doctor/physician if you experience any of the following symptoms within a few hours after taking this product: changes in mental state such as restlessness or confusion, increased heart rate, enlarged pupils, loss of muscle coordination, sweating, shivering and/or gastrointestinal symptoms such as nausea, vomiting, diarrhea. This product is not intended as a substitute for sleep. If you are taking prescription medications, consult a health care practitioner prior to use. Consult a health care practitioner prior to use if you are taking antidepressant medication, hormone replacement therapy (HRT) or birth control pills. Avoid taking with alcohol or products with sedative properties. Consult a health care practitioner prior to use if you have exterior pathogens/conditions. Known Adverse Reactions: Diuretic effect may occur. Stop use if hypersensitivity/allergy occurs. Stop use if you experience irritability or insomnia. May cause digestive problems. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Contra-Indications: Do not use this product if you are pregnant or breastfeeding. Do not use this product if you have bipolar disorder or bipolar spectrum disorder. Precautions for Use: Store in a cool dry place away from heat and light. Do not use if product has been opened or tampered with in any way. Keep out of the reach of children.

Deep Blue Mind Enhancing Blend

Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health – can culinary and medicinal mushrooms help?. J Tradit Complement Med. 2013;3(1):62-68. doi: 10.4103/2225-4110.106549

Lai, Puei-Lene; Naidu, Murali; Sabaratnam, Vikineswary; Wong, Kah-Hui; David, Rosie Pamela; Kuppusamy, Umah Rani; Abdullah, Noorlidah; Malek, Sri Nurestri A. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms ; 15(6): 539-54, 2013. DOI: 10.1615/intjmedmushr.v15.i6.30

Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014;4(1):1‐12. doi: 10.1007/s13205-013-0121-9

Panda AK, Swain KC. Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim. J Ayurveda Integr Med. 2011;2(1):9‐13. doi: 10.4103/0975-9476.78183

Wachtel-Galor S, Yuen J, Buswell JA, et al. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 9. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92757/

NeuroFactor® & DHH-B

Reyes-Izquierdo, T., Nemzer, B., Shu, C., Huynh, L., Argumedo, R., Keller, R., & Pietrzkowski, Z. (2013). Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. British Journal of Nutrition, 110(3), 420-425. doi:10.1017/S0007114512005338

Mullen, W., Nemzer, B., Ou, B., Stalmach, A., Hunter, J., Clifford, M. N., & Combet, E. (2011). The Antioxidant and Chlorogenic Acid Profiles of Whole Coffee Fruits Are Influenced by the Extraction Procedures. Journal of Agricultural and Food Chemistry, 59(8), 3754–3762. DOI: 10.1021/jf200122m

Duangjai, A., Suphrom, N., Wungrath, J., Ontawong, A., Nuengchamnong, N., & Yosboonruang, A. (2016). Comparison of antioxidant, antimicrobial activities and chemical profiles of three coffee (Coffea arabica L.) pulp aqueous extracts. Integrative Medicine Research, 5(4), 324–331. DOI: 10.1016/j.imr.2016.09.001

Bekinschtein P, Cammarota M, Katche C, et al. BDNF is essential to promote persistence of long-term memory storage. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(7):2711-2716. doi:10.1073/pnas.0711863105.

Woodbury A, Yu SP, Wei L, García P. Neuro-modulating effects of honokiol: a review. Front Neurol. 2013;4:130. Published 2013 Sep 11. doi: 10.3389/fneur.2013.00130

GABA (Gamma-Aminobutyric Acid)

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Spiering MJ. The discovery of GABA in the brain. J Biol Chem. 2018;293(49):19159‐19160. doi: 10.1074/jbc.CL118.006591

Belloni L, Savioli F, Barbieri C. [On the antihypertensive properties of gamma-aminobutyric acid. Clinical experience in 29 hypertensive patients] Archivio "E. Maragliano" di Patologia e Clinica. 1966 Feb;22(1):119-145.

H. Nakamura, T. Takishima, T. Kometani & H. Yokogoshi (2009) Psychological stress-reducing effect of chocolate enriched with γ-aminobutyric acid (GABA) in humans: assessment of stress using heart rate variability and salivary chromogranin A, International Journal of Food Sciences and Nutrition, 60:sup5, 106-113, DOI: 10.1080/09637480802558508

Abdou, Adham & Higashiguchi, S & Horie, K & Kim, Mujo & Hatta, Hajime & Yokogoshi, H. (2006). Relaxation and immunity enhancement effects of γ-Aminobutyric acid (GABA) administration in humans. BioFactors (Oxford, England). 26. 201-8. DOI: 10.1002/biof.5520260305.

Organic Alaskan Blueberries

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Mary H. Grace, Debora Esposito, Kriya L. Dunlap, and Mary Ann Lila. Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries. Journal of Agricultural and Food Chemistry 2014 62 (18), 4007-4017. DOI: 10.1021/jf403810y

Dróżdż, P., Šėžienė, V. & Pyrzynska, K. Phytochemical Properties and Antioxidant Activities of Extracts from Wild Blueberries and Lingonberries. Plant Foods Hum Nutr 72, 360–364 (2017). DOI: 10.1007/s11130-017-0640-3

Ashwagandha

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262. doi: 10.4103/0253-7176.106022

Björnsson, HK, Björnsson, ES, Avula, B, et al. Ashwagandha‐induced liver injury: A case series from Iceland and the US Drug‐Induced Liver Injury Network. Liver Int. 2020; 40: 825– 829. https://doi.org/10.1111/liv.14393

Shah, N., Singh, R., Sarangi, U., Saxena, N., Chaudhary, A., Kaur, G., Kaul, S. C., & Wadhwa, R. (2015). Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation. PloS one, 10(3), e0120554. DOI: 10.1371/journal.pone.0120554

Wadhwa, R., Singh, R., Gao, R., Shah, N., Widodo, N., Nakamoto, T., Ishida, Y., Terao, K., & Kaul, S. C. (2013). Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action. PloS one, 8(10), e77189. DOI: 10.1371/journal.pone.0077189

Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., & Wadhwa, R. (2004). Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(12), 2015–2020. DOI: 10.1016/j.fct.2004.07.015

Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus, 11(12), e6466. DOI: 10.7759/cureus.6466Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine, 98(37), e17186. DOI: 10.1097/MD.0000000000017186

Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus, 11(9), e5797. DOI: 10.7759/cureus.5797

Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study. Cureus, 12(2), e7083. DOI: 10.7759/cureus.7083

Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., & Deshpande, M. (2010). Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Central nervous system agents in medicinal chemistry, 10(3), 238–246. DOI: 10.2174/1871524911006030238

 Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Journal of alternative and complementary medicine (New York, N.Y.), 20(12), 901–908. DOI: 10.1089/acm.2014.0177

Singh, R., Gupta, P., Khan, F., Singh, S. K., Sanchita, Mishra, T., Kumar, A., Dhawan, S. S., & Shirke, P. A. (2018). Modulations in primary and secondary metabolic pathways and adjustment in physiological behaviour of Withania somnifera under drought stress. Plant science : an international journal of experimental plant biology, 272, 42–54. DOI: 10.1016/j.plantsci.2018.03.029