Historical overview

Nicotinamide Riboside (NR) might not be a household name, but this unique form of vitamin B3 has been stirring up excitement in the scientific community since its discovery in the early 21st century. Initially, NR was identified as a nutrient in milk, but it was only in 2004 that Dr. Charles Brenner discovered its potential role as a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme found in all living cells which may play a role in numerous biological processes.

The biology and chemistry of nicotinamide riboside

NR is a naturally occurring form of vitamin B3 that acts as a precursor to NAD+. This means that when consumed, NR is believed to be converted into NAD+ in the body. NAD+ is potentially important for energy metabolism and the functioning of our cells.* It could be involved in redox reactions, driving cell metabolism by accepting and donating electrons.

Moreover, NAD+ is a substrate for several enzymes, including sirtuins and poly ADP-ribose polymerases (PARPs), which may be involved in DNA repair, stress resistance, and aging.* However, as we age, NAD+ levels tend to decline, which can might alter cellular function.*

Chemically, NR is a pyridine-nucleoside, similar to nicotinamide but with a ribose sugar attached. This structure might allow it to be converted into NAD+ differently than other forms of vitamin B3.

NR+ supplements

Given the potential role of NAD+ and the fact that its levels could decline with age, scientists have been exploring ways to boost NAD+ levels in the body. That's where NR supplements, often labeled as "NR+", come in.

NR+ supplements contain NR, which might be converted into NAD+ once ingested, potentially supporting NAD+ levels and sirtuin activity.* Research suggests that boosting NAD+ levels might have several health benefits, including supporting energy metabolism, brain function, and potential healthy aging in certain populations.

However, while early research is promising, it's essential to note that much of the research to date has been conducted in mammals. More research, particularly large-scale human trials, is needed to continue understanding its role. You might also want to read about pterostilbene. 

Interesting facts about nicotinamide riboside

1. Found in Milk: NR was first identified as a trace nutrient in milk. However, you would need to consume impractical amounts of milk to get a significant dose of NR.

2. NAD+ Precursor: NR is seen as potentially more efficient at raising NAD+ levels in the body compared to other forms of vitamin B3, like niacin and nicotinamide in certain populations.*

3. Exercise and heart health: Studies in mice suggest that NR supplementation may help support exercise endurance and heart health, but these findings need to be confirmed in humans.

4. Safety profile: NR is generally well-tolerated, with few side effects. However, as with all supplements, it's recommended to consult with a healthcare provider before starting.

In summary, nicotinamide riboside is a fascinating compound that has the potential to profoundly impact human health and longevity. As research advances, we may soon see new NR+ supplements becoming a part in the quest for healthspan and lifespan as part of an healthy regimen.

As we delve deeper into the role of NAD+ and its precursors in human health, the impact of Nicotinamide Riboside continues to unfold. Its ability to potentially support NAD+ levels positions it as a promising supplement/

Emerging studies suggests that Nicotinamide Riboside could potentially play a role in mitochondrial health.* Mitochondria, known as the powerhouse of the cell, are important for energy production. As we age, mitochondrial function tends to decrease, contributing to fatigue and other age-associated conditions. 

One of the most exciting areas of research regarding Nicotinamide Riboside and NAD+ is their role in sirtuins, a group of proteins often referred to as "longevity genes." Sirtuins might play a role in supporting cellular stress, and healthy aging.* NAD+ is seen as an important co-substrate for sirtuins, meaning its availability might directly impacts sirtuin activity. Therefore, by supporting NAD+ levels, NR could potentially support sirtuins, promoting longevity and healthy aging.*

Further, recent research hints at the potential benefits of NR in supporting healthy brain function.* Studies suggest that NAD+ might play a role in neuronal health.*

Despite these promising avenues of research, it's essential to approach Nicotinamide Riboside supplementation with a critical eye as long-term studies are still lacking. As with any supplement, it's best to consult with a healthcare provider before starting.

In conclusion, Nicotinamide Riboside represents a promising frontier in the field of health and longevity. Its potential to support NAD+ levels and play a role in various aspects of health positions it as a supplement of interest for some individuals. As we continue to understand more about this unique form of vitamin B3, we may soon see NR+ becoming more of a staple in the health and wellness world.