NEXTIDA GC™ Collagen Peptides (Bovine).

As a dietary supplement to support the body’s natural GLP-1 production, adults should mix 1 scoop daily, or as recommended by your healthcare practitioner, with 8-12 ounces of water or your favorite beverage. Do not exceed the recommended serving.

CAUTION: Do not exceed recommended dose. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Pregnant or nursing mothers and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Use only as directed. Some people might experience slight intolerance to bovine product. If gastrointestinal discomfort (including bloating, cramps, diarrhea, or other digestive upset) or other sensitivity is experienced stop taking the product immediately. Some people are allergic to bovine (beef) or fish. If you are pregnant, nursing, or have a medical condition, please consult with your physician before use. If you have any questions about consuming this dietary supplement, consult with your health care professional before using. If you use prescription drugs or over-the-counter medications, are unaware of your current medical condition or have a pre-existing medical condition(s), consult with your health care professional before using. Discontinue use immediately if you experience any adverse symptoms or reactions while taking this product. Discontinue use 2 weeks prior to surgery. Do not use if your health status is unknown. Do not use if safety seal is damaged or missing. Keep out of reach of children and pets. Store in a cool, dry place, away from heat moisture. Use this product as a food supplement only. Do not use for weight reduction.

Grass-Fed Bovine Hydrolyzed Collagen

Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018;19(10):3059. Published 2018 Oct 7. doi: 10.3390/ijms19103059

Saha A, Alam MJ, Ashraf KU, Mannan A. Computational analysis of bovine alpha-1 collagen sequences. Bioinformation. 2013;9(1):42‐48. doi: 10.6026/97320630009042

León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019;24(22):4031. Published 2019 Nov 7. doi: 10.3390/molecules24224031

K. Henriksen, M.A. Karsdal, in Biochemistry of Collagens, Laminins and Elastin, 2016

Albaugh VL, Mukherjee K, Barbul A. Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. J Nutr. 2017;147(11):2011‐2017. doi:10.3945/jn.117.256404

Avila Rodríguez, MI, Rodríguez Barroso, LG, Sánchez, ML. Collagen: A review on its sources and potential cosmetic applications. J Cosmet. Dermatol. 2018; 17: 20– 26. DOI: 10.1111/jocd.12450

Paul C, Leser S, Oesser S. Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients. 2019;11(5):1079. Published 2019 May 15.  doi: 10.3945/jn.117.256404

Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 27(1), 47–55. DOI: 10.1159/000351376

Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015;114(8):1237‐1245. doi: 10.1017/S0007114515002810

Daneault, A., Prawitt, J., Fabien Soulé, V., Coxam, V., & Wittrant, Y. (2017). Biological effect of hydrolyzed collagen on bone metabolism. Critical reviews in food science and nutrition, 57(9), 1922–1937. DOI: 10.1080/10408398.2015.1038377

Hexsel, Doris & Zague, Vivian & Schunck, Michael & Siega, Carolina & Camozzato, Fernanda & Oesser, Steffen. (2017). Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. Journal of Cosmetic Dermatology. DOI: 10.1111/jocd.12393

Yazaki M, Ito Y, Yamada M, et al. Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. Journal of Agricultural and Food Chemistry. 2017 Mar;65(11):2315-2322. DOI: 10.1021/acs.jafc.6b05679 

Vitamin C

Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. 

Boyera, N., Galey, I., & Bernard, B. A. (1998). Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International journal of cosmetic science, 20(3), 151–158. DOI: 10.1046/j.1467-2494.1998.171747.x

Lis, D. M., & Baar, K. (2019). Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. International journal of sport nutrition and exercise metabolism, 29(5), 526–531. DOI: 10.1123/ijsnem.2018-0385

Kleszczewska E. (2007). Biologiczne znaczenie witaminy C ze szczególnym z uwzglednieniem jej znaczenia w metabolizmie skóry [Biological role and importance in the skin metabolism of vitamin C]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 23(138), 462–465. PMID: 18432133

DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018;6(10):2325967118804544. Published 2018 Oct 25. doi: 10.1177/2325967118804544

Moores J. (2013). Vitamin C: a wound healing perspective. British journal of community nursing, Suppl, S6–S11. DOI: 10.12968/bjcn.2013.18.sup12.s6

Collins N. (2004). Adding vitamin C to the wound management mix. Advances in skin & wound care, 17(3), 109–112. DOI: 10.1097/00129334-200404000-00010

Ronchetti, I. P., Quaglino, D., Jr, & Bergamini, G. (1996). Ascorbic acid and connective tissue. Sub-cellular biochemistry, 25, 249–264. DOI: 10.1007/978-1-4613-0325-1_13

Vaxman, F., Olender, S., Lambert, A., Nisand, G., & Grenier, J. F. (1996). Can the wound healing process be improved by vitamin supplementation? Experimental study on humans. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 28(4), 306–314. DOI: 10.1159/000129471

Hallberg, L., Brune, M., & Rossander, L. (1989). The role of vitamin C in iron absorption. International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 30, 103–108. PMID: 2507689

Lynch, S. R., & Cook, J. D. (1980). Interaction of vitamin C and iron. Annals of the New York Academy of Sciences, 355, 32–44. DOI: 10.1111/j.1749-6632.1980.tb21325.x

Teucher, B., Olivares, M., & Cori, H. (2004). Enhancers of iron absorption: ascorbic acid and other organic acids. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 74(6), 403–419. DOI: 10.1024/0300-9831.74.6.403

Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. DOI: 10.3390/nu9111211

Ströhle, A., & Hahn, A. (2009). Vitamin C und Immunfunktion [Vitamin C and immune function]. Medizinische Monatsschrift fur Pharmazeuten, 32(2), 49–56. PMID: 19263912

Hyaluronic Acid

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253‐258. doi: 10.4161/derm.21923

Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clin Cosmet Investig Dermatol. 2017;10:267‐273. Published 2017 Jul 18. doi: 10.2147/CCID.S141845

Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):27‐29. PMID: 24688623

Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. Published 2019 Jun 25. doi: 10.3389/fvets.2019.00192

Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. Published 2014 Jul 11. doi: 10.1186/1475-2891-13-70

Bowman S, Awad ME, Hamrick MW, Hunter M, Fulzele S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018;7(1):6. Published 2018 Feb 16. doi: 10.1186/s40169-017-0180-3

Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928

Altman, R., Hackel, J., Niazi, F., Shaw, P., & Nicholls, M. (2018). Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review. Seminars in arthritis and rheumatism, 48(2), 168–175. DOI: 10.1016/j.semarthrit.2018.01.009

Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC musculoskeletal disorders, 18(1), 542. DOI: 10.1186/s12891-017-1897-2

Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American journal of sports medicine, 44(8), 2158–2165. DOI: 10.1177/0363546515609599

Witteveen, A. G., Hofstad, C. J., & Kerkhoffs, G. M. (2015). Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle. The Cochrane database of systematic reviews, (10), CD010643. DOI: 10.1002/14651858.CD010643.pub2

Maheu, E., Rannou, F., & Reginster, J. Y. (2016). Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in arthritis and rheumatism, 45(4 Suppl), S28–S33. DOI: 10.1016/j.semarthrit.2015.11.008

DigeSEB® Enzyme blend

Skov K, Oxfeldt M, Thøgersen R, Hansen M, Bertram HC. Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate-A Randomized Controlled Trial. Nutrients. 2019;11(5):1064. Published 2019 May 13. doi: 10.3390/nu11051064

Mandel AL, Breslin PA. High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults. J Nutr. 2012;142(5):853‐858. doi: 10.3945/jn.111.156984

Peyrot des Gachons, C., & Breslin, P. A. (2016). Salivary Amylase: Digestion and Metabolic Syndrome. Current diabetes reports, 16(10), 102. DOI: 10.1007/s11892-016-0794-7

Ianiro G, Pecere S, Giorgio V, Gasbarrini A, Cammarota G. Digestive Enzyme Supplementation in Gastrointestinal Diseases. Curr Drug Metab. 2016;17(2):187‐193. doi: 10.2174/138920021702160114150137

Roxas M. (2008). The role of enzyme supplementation in digestive disorders. Alternative medicine review : a journal of clinical therapeutic, 13(4), 307–314. PMID: 19152478

Quintarelli, G., Dellovo, M.C., Balduini, C. et al. The effects of alpha amylase on collagen-proteoglycans and collagen-glycoprotein complexes in connective tissue matrices. Histochemie 18, 373–375 (1969). DOI: 10.1007/BF00279887

Felicilda-Reynaldo, R. F., & Kenneally, M. (2016). Digestive Enzyme Replacement Therapy: Pancreatic Enzymes and Lactase. Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses, 25(3), 182–185. PMID: 27522847

Das, S. K., Varadhan, S., Dhanya, L., Mukherjee, S., Mohana, S., Balakrishnan, V., & Vasudevan, D. M. (2009). Diagnostic efficiency of amylase and type IV collagen in predicting chronic pancreatitis. Indian journal of clinical biochemistry : IJCB, 24(1), 60–64. doi: 10.1007/s12291-009-0010-5

Levine, M. E., Koch, S. Y., & Koch, K. L. (2015). Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects. Gut and liver, 9(4), 464–469. doi: 10.5009/gnl14005

Park, S. Y., & Rew, J. S. (2015). Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?. Gut and liver, 9(4), 433–434. doi: 10.5009/gnl15206

Fernandez, S., Jannin, V., Rodier, J. D., Ritter, N., Mahler, B., & Carrière, F. (2007). Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters. Biochimica et biophysica acta, 1771(5), 633–640. DOI: 10.1016/j.bbalip.2007.02.009

Dewei, S., Min, C., & Haiming, C. (2016). Collagen-Immobilized Lipases Show Good Activity and Reusability for Butyl Butyrate Synthesis. Applied biochemistry and biotechnology, 180(5), 826–840. DOI: 10.1007/s12010-016-2136-2

Du, L., Pang, H., Wang, Z., Lu, J., Wei, Y., & Huang, R. (2013). Characterization of an invertase with pH tolerance and truncation of its N-terminal to shift optimum activity toward neutral pH. PloS one, 8(4), e62306. doi: 10.1371/journal.pone.0062306

Benkeblia, N & Yoshida, N & Ooi, Y & Nagamine, T & Onodera, S & Shiomi, Norio. (2008). Variations of Carbohydrate Content and Invertase Activity in Green and White Asparagus Spears - Effects of Spear Length and Portion. Acta Horticulturae. 776. DOI: 10.17660/ActaHortic.2008.776.59

Lee, B. H., Lin, A. H., Nichols, B. L., Jones, K., Rose, D. R., Quezada-Calvillo, R., & Hamaker, B. R. (2014). Mucosal C-terminal maltase-glucoamylase hydrolyzes large size starch digestion products that may contribute to rapid postprandial glucose generation. Molecular nutrition & food research, 58(5), 1111–1121. DOI: 10.1002/mnfr.201300599

Di Nardo G, Oliva S, Ferrari F, et al. Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial. BMC Gastroenterol. 2013;13:142. Published 2013 Sep 24. doi: 10.1186/1471-230X-13-142

Ganiats, T. G., Norcross, W. A., Halverson, A. L., Burford, P. A., & Palinkas, L. A. (1994). Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. The Journal of family practice, 39(5), 441–445. PMID: 7964541

Di Stefano, M., Miceli, E., Gotti, S., Missanelli, A., Mazzocchi, S., & Corazza, G. R. (2007). The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. Digestive diseases and sciences, 52(1), 78–83. DOI: 10.1007/s10620-006-9296-9

Amino acids

Gauthier NP, Soufi B, Walkowicz WE, et al. Cell-selective labeling using amino acid precursors for proteomic studies of multicellular environments. Nat Methods. 2013;10(8):768‐773. doi: 10.1038/nmeth.2529

Poos MI, Costello R, Carlson-Newberry SJ; Institute of Medicine (US) Committee on Military Nutrition Research. Committee on Military Nutrition Research: Activity Report: December 1, 1994 through May 31, 1999. Washington (DC): National Academies Press (US); 1999. The Role of Protein and Amino Acids in Sustaining and Enhancing Performance.

Institute of Medicine (US) Committee on Military Nutrition Research. The Role of Protein and Amino Acids in Sustaining and Enhancing Performance. Washington (DC): National Academies Press (US); 1999. 14, Amino Acid and Protein Requirements: Cognitive Performance, Stress, and Brain Function.

Nair, K. S., & Short, K. R. (2005). Hormonal and signaling role of branched-chain amino acids. The Journal of nutrition, 135(6 Suppl), 1547S–52S. DOI: 10.1093/jn/135.6.1547S

Fernstrom J. D. (1994). Dietary amino acids and brain function. Journal of the American Dietetic Association, 94(1), 71–77. DOI: 10.1016/0002-8223(94)92045-1

Mathai, J. K., Liu, Y., & Stein, H. H. (2017). Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein digestibility-corrected amino acid scores (PDCAAS). The British journal of nutrition, 117(4), 490–499. DOI: 10.1017/S0007114517000125

Huecker, M., Sarav, M., Pearlman, M., & Laster, J. (2019). Protein Supplementation in Sport: Source, Timing, and Intended Benefits. Current nutrition reports, 8(4), 382–396. DOI: 10.1007/s13668-019-00293-1

Amasene, M., Besga, A., Echeverria, I., Urquiza, M., Ruiz, J. R., Rodriguez-Larrad, A., Aldamiz, M., Anaut, P., Irazusta, J., & Labayen, I. (2019). Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial. Nutrients, 11(10), 2337. DOI: 10.3390/nu11102337

Arentson-Lantz, E. J., Galvan, E., Ellison, J., Wacher, A., & Paddon-Jones, D. (2019). Improving Dietary Protein Quality Reduces the Negative Effects of Physical Inactivity on Body Composition and Muscle Function. The journals of gerontology. Series A, Biological sciences and medical sciences, 74(10), 1605–1611. DOI: 10.1093/gerona/glz003

Darragh, A. J., & Hodgkinson, S. M. (2000). Quantifying the digestibility of dietary protein. The Journal of nutrition, 130(7), 1850S–6S. DOI: 10.1093/jn/130.7.1850S