Complexe multi-collagène : peptides de collagène bovin hydrolysé nourris à l'herbe, collagène de bouillon d'os de poulet biologique, collagène de membrane de coquille d'œuf, acide hyaluronique. Autres ingrédients : Capsule de méthylcellulose.

Profil d'acides aminés (milligrammes moyens par portion) : Alanine 139 mg, Arginine 118 mg, Acide aspartique 89 mg, Acide glutamique 157 mg, Glycine 374 mg, Histidine 12 mg, Hydroxylysine 14 mg, Hydroxyproline 182 mg, Isoleucine 24 mg, Leucine 46 mg, Lysine 57 mg, Méthionine 14 mg, Phénylalanine 30 mg, Proline 217 mg, Sérine 52 mg, Thréonine 28 mg, Tyrosine 8 mg, Valine 35 mg. Contient huit des neuf acides aminés essentiels. Ne contient pas de tryptophane, un acide aminé essentiel. Milligrammes moyens par portion d'origine naturelle ; les valeurs absolues peuvent varier.

Contient : Œuf.

Prendre 3 capsules par jour avec 8 onces d'eau ou votre boisson préférée. Peut être pris avec ou sans nourriture.

ATTENTION : Ne dépassez pas la dose recommandée. Veuillez faire preuve de prudence si vous avez des allergies ou des sensibilités à l’un des ingrédients répertoriés. Les mères enceintes ou allaitantes et les personnes souffrant d'un problème de santé connu doivent consulter un médecin avant d'utiliser ce produit ou tout autre complément alimentaire. Utiliser uniquement comme indiqué. Certaines personnes peuvent ressentir une légère intolérance aux produits marins ou bovins. En cas d'inconfort gastro-intestinal (y compris ballonnements, crampes, diarrhée ou autres troubles digestifs) ou d'une autre sensibilité, arrêtez immédiatement de prendre le produit. Certaines personnes sont allergiques au bovin (bœuf) ou au poisson. Si vous êtes enceinte, allaitez ou avez un problème de santé, veuillez consulter votre médecin avant utilisation. Si vous avez des questions sur la consommation de ce complément alimentaire, consultez votre professionnel de la santé avant de l'utiliser. Si vous utilisez des médicaments sur ordonnance ou en vente libre, si vous ignorez votre état de santé actuel ou si vous avez un ou plusieurs problèmes de santé préexistants, consultez votre professionnel de la santé avant de l'utiliser. Arrêtez immédiatement l'utilisation si vous ressentez des symptômes ou des réactions indésirables pendant la prise de ce produit. Arrêtez l'utilisation 2 semaines avant la chirurgie. Ne pas utiliser si votre état de santé est inconnu. Ne pas utiliser si le sceau de sécurité est endommagé ou manquant. Tenir hors de portée des enfants et des animaux de compagnie. Conserver dans un endroit frais et sec, à l'abri de la chaleur et de l'humidité. Utilisez ce produit uniquement comme complément alimentaire. Ne pas utiliser pour la réduction de poids.

Grass-Fed Hydrolyzed Bovine Collagen Peptides

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Daneault, A., Prawitt, J., Fabien Soulé, V., Coxam, V., & Wittrant, Y. (2017). Biological effect of hydrolyzed collagen on bone metabolism. Critical reviews in food science and nutrition, 57(9), 1922–1937. DOI: 10.1080/10408398.2015.1038377

Hexsel, Doris & Zague, Vivian & Schunck, Michael & Siega, Carolina & Camozzato, Fernanda & Oesser, Steffen. (2017). Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. Journal of Cosmetic Dermatology. DOI: 10.1111/jocd.12393

Yazaki M, Ito Y, Yamada M, et al. Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. Journal of Agricultural and Food Chemistry. 2017 Mar;65(11):2315-2322. DOI: 10.1021/acs.jafc.6b05679 

Organic Chicken Bone Broth

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Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016;48(2):95‐101. doi: 10.5152/eurasianjmed.2015.15030

Lugo, J.P., Saiyed, Z.M. & Lane, N.E. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J 15, 14 (2015). DOI: 10.1186/s12937-016-0130-8

Bagchi, D., Misner, B., Bagchi, M., Kothari, S. C., Downs, B. W., Fafard, R. D., & Preuss, H. G. (2002). Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. International journal of clinical pharmacology research, 22(3-4), 101–110.

Zhu, P., Li, X. Y., Wang, H. K., Jia, J. F., Zheng, Z. H., Ding, J., & Fan, C. M. (2007). Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis. Clinical immunology (Orlando, Fla.), 122(1), 75–84. DOI: 10.1016/j.clim.2006.08.004

Barnett, M. L., Kremer, J. M., St Clair, E. W., Clegg, D. O., Furst, D., Weisman, M., Fletcher, M. J., Chasan-Taber, S., Finger, E., Morales, A., Le, C. H., & Trentham, D. E. (1998). Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis and rheumatism, 41(2), 290–297. DOI: 10.1002/1529-0131(199802)41:2<290::AID-ART13>3.0.CO;2-R

Yoshinari, O., Moriyama, H., & Shiojima, Y. (2015). An overview of a novel, water-soluble undenatured type II collagen (NEXT-II). Journal of the American College of Nutrition, 34(3), 255–262. DOI: 10.1080/07315724.2014.919541

Paul, C., Leser, S., & Oesser, S. (2019). Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients, 11(5), 1079. DOI: 10.3390/nu11051079

Darling, A. L., Manders, R., Sahni, S., Zhu, K., Hewitt, C. E., Prince, R. L., Millward, D. J., & Lanham-New, S. A. (2019). Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30(4), 741–761. DOI: 10.1007/s00198-019-04933-8

Lerman, R. H., Chang, J. L., Konda, V., Desai, A., & Montalto, M. B. (2015). Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report. Integrative medicine (Encinitas, Calif.), 14(5), 52–61. PMCID: PMC4712866

Egg Shell Membrane Collagen

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Ruff KJ, Winkler A, Jackson RW, DeVore DP, Ritz BW. Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study. Clin Rheumatol. 2009;28(8):907‐914. doi: 10.1007/s10067-009-1173-4

Hewlings, S., Kalman, D., & Schneider, L. V. (2019). A Randomized, Double-Blind, Placebo-Controlled, Prospective Clinical Trial Evaluating Water-Soluble Chicken Eggshell Membrane for Improvement in Joint Health in Adults with Knee Osteoarthritis. Journal of medicinal food, 22(9), 875–884. DOI: 10.1089/jmf.2019.0068

Ruff, K. J., DeVore, D. P., Leu, M. D., & Robinson, M. A. (2009). Eggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clinical interventions in aging, 4, 235–240. DOI: 10.2147/cia.s5797

Hyaluronic Acid

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Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):27‐29. PMID: 24688623

Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. Published 2019 Jun 25. doi: 10.3389/fvets.2019.00192

Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. Published 2014 Jul 11. doi: 10.1186/1475-2891-13-70

Bowman S, Awad ME, Hamrick MW, Hunter M, Fulzele S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018;7(1):6. Published 2018 Feb 16. doi: 10.1186/s40169-017-0180-3

Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928

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Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC musculoskeletal disorders, 18(1), 542. DOI: 10.1186/s12891-017-1897-2

Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American journal of sports medicine, 44(8), 2158–2165. DOI: 10.1177/0363546515609599

Witteveen, A. G., Hofstad, C. J., & Kerkhoffs, G. M. (2015). Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle. The Cochrane database of systematic reviews, (10), CD010643. DOI: 10.1002/14651858.CD010643.pub2

Maheu, E., Rannou, F., & Reginster, J. Y. (2016). Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in arthritis and rheumatism, 45(4 Suppl), S28–S33. DOI: 10.1016/j.semarthrit.2015.11.008

Vitamin C

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Kleszczewska E. (2007). Biologiczne znaczenie witaminy C ze szczególnym z uwzglednieniem jej znaczenia w metabolizmie skóry [Biological role and importance in the skin metabolism of vitamin C]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 23(138), 462–465. PMID: 18432133

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Moores J. (2013). Vitamin C: a wound healing perspective. British journal of community nursing, Suppl, S6–S11. DOI: 10.12968/bjcn.2013.18.sup12.s6

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