Vitamina C (como ácido ascórbico), vitamina E (como acetato de d-alfa tocoferol), tiamina (vitamina B1; como tiamina HCl), riboflavina (vitamina B2), niacina (como niacinamida), vitamina B6 (como piridoxina HCl), folato (como ácido fólico), biotina, ácido pantoténico (vitamina B5; como pantotenato de calcio), selenio (como selenometionina), mezcla de alimentos orgánicos: Sesbania grandiflora orgánica (hoja), guayaba orgánica (Psidium guajava; fruta), baya de Amla orgánica (fruta ), Albahaca Sagrada Orgánica (Ocimum tenuiflorum; hoja), Limón Orgánico (cáscara), Achiote Orgánico (hoja), Bambú Orgánico (brote), Mostaza Orgánica (semilla), Sílice (Dióxido de Silicio), Fitoceramidas, Astaxantina Orgánica. Otros ingredientes: Cápsula de metilcelulosa.

Tome 3 cápsulas al día con 8 onzas de agua o su bebida favorita. Puede tomarse con o sin alimentos.

PRECAUCIÓN: No exceda la dosis recomendada. Es importante saber que no se puede perder peso utilizando solo el producto o sin seguir una dieta controlada en calorías y un programa de ejercicios. Es posible que los resultados de la pérdida de peso no sean efectivos para todos y que los resultados no sean permanentes. Las mujeres embarazadas, las madres lactantes, los niños menores de 18 años y las personas con una afección médica conocida deben consultar a un médico antes de usar este o cualquier suplemento dietético. Tenga cuidado si tiene alergias o sensibilidades a alguno de los ingredientes enumerados. Mantener fuera del alcance de los niños y las mascotas. No lo utilice si el sello de seguridad está dañado o falta. Guardar en un lugar fresco y seco. La biotina se puede obtener en cantidades adecuadas o adicionales únicamente a través de los alimentos y la dieta habitual. Utilice este producto únicamente como complemento alimenticio. No utilice para la reducción de peso.

Biotin

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Janos Zempleni, Yousef I Hassan & Subhashinee SK Wijeratne (2008) Biotin and biotinidase deficiency, Expert Review of Endocrinology & Metabolism, 3:6, 715-724, DOI: 10.1586/17446651.3.6.715

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981

S. Daniells and G. Hardy, “Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame?” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 13, no. 6, pp. 690–697, November 2010. doi: 10.1097/MCO.0b013e32833ece02

Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715

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Sparavigna A, Tenconi B, La Penna L. Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial. Clin Cosmet Investig Dermatol. 2019;12:355‐362. Published 2019 May 13. doi: 10.2147/CCID.S187305

Lipner, S. R., & Scher, R. K. (2018). Biotin for the treatment of nail disease: what is the evidence?. The Journal of dermatological treatment, 29(4), 411–414. DOI: 10.1080/09546634.2017.1395799

Victor E. Colombo, Françoise Gerber, Max Bronhofer, George L. Floersheim. Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy. Colombo, Victor E. et al. Journal of the American Academy of Dermatology, Volume 23, Issue 6, 1127 – 1132. DOI: https://doi.org/10.1016/0190-9622(90)70345-I

Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi: 10.4103/0974-7753.188040

Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 41–48. PMID: 2648686

Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303–305. PMID: 8477615

Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782–787. PMID: 17763607

Full-spectrum Vitamin B

Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016;8(2):68. Published 2016 Jan 27. doi: 10.3390/nu8020068

Schellack, G. & Harirari, P. & Schellack, Natalie. (2015). B-complex vitamin deficiency and supplementation. 82. 28-32.

Young LM, Pipingas A, White DJ, Gauci S, Scholey A. A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals. Nutrients. 2019;11(9):2232. Published 2019 Sep 16. doi: 10.3390/nu11092232

Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020;12(1):228. Published 2020 Jan 16. doi: 10.3390/nu12010228

McCabe, D., Lisy, K., Lockwood, C., & Colbeck, M. (2017). The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI database of systematic reviews and implementation reports, 15(2), 402–453. DOI: 10.11124/JBISRIR-2016-002965

Long, S. J., & Benton, D. (2013). Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis. Psychosomatic medicine, 75(2), 144–153. DOI: 10.1097/PSY.0b013e31827d5fbd

Vitamin C

Chambial S, Dwivedi S, Shukla KK, John PJ, Sharma P. Vitamin C in disease prevention and cure: an overview. Indian J Clin Biochem. 2013;28(4):314‐328.  doi: 10.1007/s12291-013-0375-3

Traber MG, Stevens JF. Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med. 2011;51(5):1000‐1013. doi: 10.1016/j.freeradbiomed.2011.05.017

Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J. H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., & Levine, M. (2003). Vitamin C as an antioxidant: evaluation of its role in disease prevention. Journal of the American College of Nutrition, 22(1), 18–35. DOI: 10.1080/07315724.2003.10719272

Pehlivan, Fadime. (2017). Vitamin C: An Antioxidant Agent. 10.5772/intechopen.69660. DOI: 10.5772/intechopen.69660

A. Bendich, L.J. Machlin, O. Scandurra, G.W. Burton, D.D.M. Wayner, The antioxidant role of vitamin C, Advances in Free Radical Biology & Medicine, Volume 2, Issue 2, 1986, 419-444, 8755-9668. https://doi.org/10.1016/S8755-9668(86)80021-7

Marc Bürzle, Matthias A. Hediger. Chapter Eleven: Functional and Physiological Role of Vitamin C Transporters. Mark O. Bevensee. Current Topics in Membranes. Academic Press. 70. 2012. 357-375. 1063-5823. 9780123943163. https://doi.org/10.1016/B978-0-12-394316-3.00011-9

Akbari, Abolfazl & Jelodar, Gholamali & Nazifi, Saeed & Sajedianfard, Javad. (2016). An Overview of The characteristics and Function of Vitamin C in Various Tissues: Relying on its Antioxidant Function. Zahedan Journal of Research in Medical Sciences. In Press. DOI: 10.17795/zjrms-4037

Chakraborthy, Aratirika & Ramani, Pratibha & Sherlin, Herald & Premkumar, Priya & Natesan, Anuja. (2014). Antioxidant and pro-oxidant activity of Vitamin C in oral environment. Indian journal of dental research : official publication of Indian Society for Dental Research. 25. 499-504. DOI: 10.4103/0970-9290.142547

Sirmali, Rana & Giniş, Zeynep & Sirmali, Mehmet & Solak, Okan & Şeliman, Bengü & Ağaçkiran, Yetkin & Delibaş, Namık. (2014). Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. Turkish journal of medical sciences. 44. 905-13. DOI: 10.3906/sag-1309-139

Organic Astaxanthin

Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications--a review. Mar Drugs. 2014;12(1):128-152. Published 2014 Jan 7. doi: 10.3390/md12010128

Davinelli, S., Nielsen, M. E., & Scapagnini, G. (2018). Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review. Nutrients, 10(4), 522. DOI: 10.3390/nu10040522

Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006). Astaxanthin: a review of its chemistry and applications. Critical reviews in food science and nutrition, 46(2), 185–196. DOI: 10.1080/10408690590957188

Yuan, J. P., Peng, J., Yin, K., & Wang, J. H. (2011). Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Molecular nutrition & food research, 55(1), 150–165. DOI: 10.1002/mnfr.201000414

Hussein, G., Sankawa, U., Goto, H., Matsumoto, K., & Watanabe, H. (2006). Astaxanthin, a carotenoid with potential in human health and nutrition. Journal of natural products, 69(3), 443–449. DOI: 10.1021/np050354+

Organic Food Blend

Gutiérrez, R. M., Mitchell, S., & Solis, R. V. (2008). Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology, 117(1), 1–27. DOI: 10.1016/j.jep.2008.01.025

Díaz-de-Cerio, E., Verardo, V., Gómez-Caravaca, A. M., Fernández-Gutiérrez, A., & Segura-Carretero, A. (2017). Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade. International journal of molecular sciences, 18(4), 897. DOI: 10.3390/ijms18040897

Qadan, F., Thewaini, A. J., Ali, D. A., Afifi, R., Elkhawad, A., & Matalka, K. Z. (2005). The antimicrobial activities of Psidium guajava and Juglans regia leaf extracts to acne-developing organisms. The American journal of Chinese medicine, 33(2), 197–204. DOI: 10.1142/S0192415X05002783

Masaki H. (2010). Role of antioxidants in the skin: anti-aging effects. Journal of dermatological science, 58(2), 85–90. DOI: 10.1016/j.jdermsci.2010.03.003

Kim, S. Y., Kim, E. A., Kim, Y. S., Yu, S. K., Choi, C., Lee, J. S., Kim, Y. T., Nah, J. W., & Jeon, Y. J. (2016). Protective effects of polysaccharides from Psidium guajava leaves against oxidative stresses. International journal of biological macromolecules, 91, 804–811. DOI: 10.1016/j.ijbiomac.2016.05.111

Doubova, S. V., Morales, H. R., Hernández, S. F., del Carmen Martínez-García, M., de Cossío Ortiz, M. G., Soto, M. A., Arce, E. R., & Lozoya, X. (2007). Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: a randomized clinical trial. Journal of ethnopharmacology, 110(2), 305–310. DOI: 10.1016/j.jep.2006.09.033

Panee J. Potential Medicinal Application and Toxicity Evaluation of Extracts from Bamboo Plants. J Med Plant Res. 2015;9(23):681-692. DOI: 10.5897/jmpr2014.5657 

Yu, Y., Li, Z., Cao, G., Huang, S., & Yang, H. (2019). Bamboo Leaf Flavonoids Extracts Alleviate Oxidative Stress in HepG2 Cells via Naturally Modulating Reactive Oxygen Species Production and Nrf2-Mediated Antioxidant Defense Responses. Journal of food science, 84(6), 1609–1620. DOI: 10.1111/1750-3841.14609

Singhal, P., Bal, L. M., Satya, S., Sudhakar, P., & Naik, S. N. (2013). Bamboo shoots: a novel source of nutrition and medicine. Critical reviews in food science and nutrition, 53(5), 517–534. DOI: 10.1080/10408398.2010.531488

Hu C, Zhang Y, Kitts DD. Evaluation of antioxidant and prooxidant activities of bamboo Phyllostachys nigra var. Henonis leaf extract in vitro. Journal of Agricultural and Food Chemistry. 2000 Aug;48(8):3170-3176. DOI: 10.1021/jf0001637

Nongdam, Potshangbam & Tikendra, Leimapokpam. (2014). The Nutritional Facts of Bamboo Shoots and Their Usage as Important Traditional Foods of Northeast India. International Scholarly Research Notices. 2014. 1-17. DOI: 10.1155/2014/679073

Jamshidi N, Cohen MM. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Alternat Med. 2017;2017:9217567. doi: 10.1155/2017/9217567

Cohen MM. Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med. 2014;5(4):251-259. doi: 10.4103/0975-9476.146554

Baliga, M. S., & Dsouza, J. J. (2011). Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 20(3), 225–239. DOI: 10.1097/CEJ.0b013e32834473f4

Scartezzini, P., Antognoni, F., Raggi, M. A., Poli, F., & Sabbioni, C. (2006). Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn. Journal of ethnopharmacology, 104(1-2), 113–118. DOI: 10.1016/j.jep.2005.08.065

Fujii, T., Wakaizumi, M., Ikami, T., & Saito, M. (2008). Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. Journal of ethnopharmacology, 119(1), 53–57. DOI: 10.1016/j.jep.2008.05.039

Chen, T. S., Liou, S. Y., & Chang, Y. L. (2009). Supplementation of Emblica officinalis (Amla) extract reduces oxidative stress in uremic patients. The American journal of Chinese medicine, 37(1), 19–25. DOI: 10.1142/S0192415X09006680

Poltanov, E. A., Shikov, A. N., Dorman, H. J., Pozharitskaya, O. N., Makarov, V. G., Tikhonov, V. P., & Hiltunen, R. (2009). Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements. Phytotherapy research : PTR, 23(9), 1309–1315. DOI: 10.1002/ptr.2775

Chen, T. S., Liou, S. Y., Wu, H. C., Tsai, F. J., Tsai, C. H., Huang, C. Y., & Chang, Y. L. (2011). Efficacy of epigallocatechin-3-gallate and Amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients. Journal of medicinal food, 14(7-8), 718–723. DOI: 10.1089/jmf.2010.1195

Zhao T, Sun Q, Marques M, Witcher M. Anticancer Properties of Phyllanthus emblica (Indian Gooseberry). Oxid Med Cell Longev. 2015;2015:950890. doi: 10.1155/2015/950890