Setria® L-Glutathione, Phospholipid Complex (from Non-GMO Sunflower Oil and Lecithin). Other Ingredients: Methylcellulose Capsule.

Take 2 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.

CAUTION: Do not exceed recommended dose. Pregnant, nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Keep out of reach of children and pets. Do not use if safety seal is damaged or missing. Store in a cool dry place. Use this product as a food supplement only. Do not use for weight reduction.

Master antioxidant. A liposomal form of one of the body's most important antioxidant and detoxification factors.

Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12. See abstract and sections 1-3 for a summary of glutathione’s role as an antioxidant and as a detoxifying compound. 

Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12. PMID: 26770075; PMCID: PMC4684116. See pages 8-10 for a description of the role of glutathione in antioxidant pathways and in detoxification.

Sinha R, Sinha I, Calcagnotto A, Trushin N, Haley JS, Schell TD, Richie JP Jr. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018 Jan;72(1):105-111.

Study shows increased body glutathione following administration in liposomal form.  Results also show a reduction in oxidation biomarkers, attesting to its antioxidant capabilities.  See Abstract (page 1); Results (pages 4-6 and Figures 3 and 4).

Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63.

See Results section for confirmation of increased blood glutathione as well as a reduction in oxidation.

Glutathione may provide antioxidant support for the liver, brain, heart, lung, eyes and immune system.

Glutathione: overview of its protective roles, measurement, and biosynthesis.

Forman HJ, Zhang H, Rinna A.Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12. 

See abstract and sections 1-3 for a summary of glutathione’s role as and antioxidant and as a detoxifying compound.

Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12. PMID: 26770075; PMCID: PMC4684116. 

See pages 8-10 for a description of glutathione’s role in antioxidant and detoxification pathways.

See page 11 Table 2 for a list of body systems affected by glutathione depletion.  These include liver, brain, heart, lung and eyes.  Citations by Forman and Pizzorno listed above make note of glutathione’s presence in nearly all cells.

Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63.

See Results section for confirmation of increased blood glutathione as well as a reduction in oxidation and positive changes in immune markers.

Glutathione may play a key role in the body’s response to physical activity

Sen CK. Glutathione homeostasis in response to exercise training and nutritional supplements. Mol Cell Biochem. 1999 Jun;196(1-2):31-42. PMID: 10448900.

Glutathione, in its role as a key antioxidant, aids in helping muscle respond to increased oxidation that occurs during exercise.

Setria®️ L-Glutathione 

Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017;10:147‐153. Published 2017 Apr 27. doi: 10.2147/CCID.S128339

Gaucher C, Boudier A, Bonetti J, Clarot I, Leroy P, Parent M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants (Basel). 2018;7(5):62. Published 2018 Apr 27. doi: 10.3390/antiox7050062

Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., Yoneda, M., Kataoka, K., Taguri, M., Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Oeda, S., Eguchi, Y., Aoi, W., … Nakajima, A. (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC gastroenterology, 17(1), 96. DOI: 10.1186/s12876-017-0652-3

Perricone, C., De Carolis, C., & Perricone, R. (2009). Glutathione: a key player in autoimmunity. Autoimmunity reviews, 8(8), 697–701. DOI: 10.1016/j.autrev.2009.02.020

Rose, S., Melnyk, S., Pavliv, O., Bai, S., Nick, T. G., Frye, R. E., & James, S. J. (2012). Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Translational psychiatry, 2(7), e134. DOI: 10.1038/tp.2012.61

Kerksick C, Willoughby D. The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. J Int Soc Sports Nutr. 2005;2(2):38‐44. Published 2005 Dec 9. doi: 10.1186/1550-2783-2-2-38

Hakki Kalkan I, Suher M. The relationship between the level of glutathione, impairment of glucose metabolism and complications of diabetes mellitus. Pak J Med Sci. 2013;29(4):938‐942. doi: 10.12669/pjms.294.2859

Tessier F, Margaritis I, Richard MJ, Moynot C, Marconnet P. Selenium and training effects on the glutathione system and aerobic performance. Medicine and Science in Sports and Exercise. 1995 Mar;27(3):390-396. PMID: 7752866

Sacco, R., Eggenhoffner, R., & Giacomelli, L. (2016). Glutathione in the treatment of liver diseases: insights from clinical practice. Minerva gastroenterologica e dietologica, 62(4), 316–324. PMID: 27603810

Gibson SA, Korade Ž, Shelton RC. Oxidative stress and glutathione response in tissue cultures from persons with major depression. J Psychiatr Res. 2012;46(10):1326‐1332. doi: 10.1016/j.jpsychires.2012.06.008

Lapidus, K. A., Gabbay, V., Mao, X., Johnson, A., Murrough, J. W., Mathew, S. J., & Shungu, D. C. (2014). In vivo (1)H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder. Neuroscience letters, 569, 74–79. DOI: 10.1016/j.neulet.2014.03.056

Adeoye O, Olawumi J, Opeyemi A, Christiania O. Review on the role of glutathione on oxidative stress and infertility. JBRA Assisted Reproduction. 2018 Mar;22(1):61-66. DOI: 10.5935/1518-0557.20180003

Grucza, K., Chołbiński, P., Kwiatkowska, D., Szutowski, M.M., & Techasen, A. (2019). Effects of Supplementation with Glutathione and its Precursors on Athlete Performance. Biomedical Journal of Scientific and Technical Research, 12, 001-008. DOI: 10.26717/BJSTR.2019.12.002293

Aoi W, Ogaya Y, Takami M, et al. Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism. J Int Soc Sports Nutr. 2015;12:7. Published 2015 Feb 6. doi: 10.1186/s12970-015-0067-x

Buonocore D, Grosini M, Giardina S, et al. Bioavailability Study of an Innovative Orobuccal Formulation of Glutathione. Oxid Med Cell Longev. 2016;2016:3286365. doi: 10.1155/2016/3286365

Chiang GC, Mao X, Kang G, et al. Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with ¹H-MRS and Pittsburgh Compound-B PET. AJNR Am J Neuroradiol. 2017;38(6):1130‐1137. doi: 10.3174/ajnr.A5143

Dringen, R., & Hirrlinger, J. (2003). Glutathione pathways in the brain. Biological chemistry, 384(4), 505–516. DOI: 10.1515/BC.2003.059

Dwivedi, D., Megha, K., Mishra, R., & Mandal, P. K. (2020). Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders. Neurochemical research, 10.1007/s11064-020-03030-1. Advance online publication. DOI: 10.1007/s11064-020-03030-1

Tong, J., Fitzmaurice, P. S., Moszczynska, A., Mattina, K., Ang, L. C., Boileau, I., Furukawa, Y., Sailasuta, N., & Kish, S. J. (2016). Do glutathione levels decline in aging human brain?. Free radical biology & medicine, 93, 110–117. DOI: 10.1016/j.freeradbiomed.2016.01.029

Sekhar R, Kumar P, Liu C. REVERSING AGING: PREVENTING AGE-RELATED DECLINE IN GLUTATHIONE AND MITOCHONDRIAL FUNCTION INCREASES LONGEVITY. Innov Aging. 2018;2(Suppl 1):887. Published 2018 Nov 16. doi: 10.1093/geroni/igy031.3309

Phospholipid Complex

Shade CW. Liposomes as Advanced Delivery Systems for Nutraceuticals. Integr Med (Encinitas). 2016;15(1):33‐36. PMID: 27053934

Abu Lila, A. S., & Ishida, T. (2017). Liposomal Delivery Systems: Design Optimization and Current Applications. Biological & pharmaceutical bulletin, 40(1), 1–10. DOI: 10.1248/bpb.b16-00624

Kuche, K., Bhargavi, N., Dora, C.P. et al. Drug-Phospholipid Complex—a Go Through Strategy for Enhanced Oral Bioavailability. AAPS PharmSciTech 20, 43 (2019). DOI: 10.1208/s12249-018-1252-4

Gnananath K, Sri Nataraj K, Ganga Rao B. Phospholipid Complex Technique for Superior Bioavailability of Phytoconstituents. Adv Pharm Bull. 2017;7(1):35‐42. doi: 10.15171/apb.2017.005

Brook, J. G., Linn, S., & Aviram, M. (1986). Dietary soya lecithin decreases plasma triglyceride levels and inhibits collagen- and ADP-induced platelet aggregation. Biochemical medicine and metabolic biology, 35(1), 31–39. DOI: 10.1016/0885-4505(86)90055-1

Young, S.A., & Smith, T.K. (2015). Lipids and Liposomes in the Enhancement of Health and Treatment of Disease. DOI: 10.5772/59665